Calcium, Oxygen Radicals and Cellular Damage (Society for by C. J. Duncan

By C. J. Duncan

This quantity files the court cases of a gathering held via the Society for Experimental Biology that tried to figure out even if there are universal mechanisms of mobile harm and to discover the ways that calcium and oxygen radicals could engage to generate the wear.

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Extra info for Calcium, Oxygen Radicals and Cellular Damage (Society for Experimental Biology Seminar Series)

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In addition, Ca2+ is involved in the regulation of chromatin conformation (P. , unpublished observations) and in conjunction with other stimuli may regulate the expression of genes such as c-fos and c-myc. Since the expression of these genes is also modulated by protein kinase C, our laboratory has recently started to investigate the potential role of protein kinase C in oxidative stress-mediated tumor promotion. , 1989&). Only the cytosolic protein kinase C displayed the increase in specific activity (Table 1) whereas the activity of the membrane-bound form remained unchanged.

FMet-Leu-Phe B. PMA +quin-2 - quin-2 1 2 3 Time (min) 4 5 2 4 6 Time (min) Fig. 3. Dependence of O2 secretion upon intracellular Ca 2+. Neutrophils (108/ml) were incubated for 10 min in the presence (O) and absence (•) of 500 uM Quin-2-AM at 37 °C. Suspensions were then diluted 10-fold in prewarmed medium and incubated for a further 20 min. 1 ug/ml PMA (B). Absorbance changes were then monitored at 550 nm using a Perkin-Elmer Lambda 5 doublebeam spectrophotometer, the reference cuvette containing the above constituents plus superoxide dismutase.

1990). Apoptosis: The role of the endonuclease. American Journal of Pathology 136, 593-608. , Manzo, L. & Orrenius, S. (1990). Tributyltin stimulates apoptosis in rat thymocytes. Archives of Biochemistry and Biophysics (in press). , Iosi, F. & Orrenius, S. (1990^). The cytoskeleton as a target in quinone toxicity. Free Radical Research Communications 8, 391-9. , Nicotera, P. & Orrenius, S. (1990b). TNF-alfa kills adenocarcinoma cells by an increase in nuclear free Ca2+ concentration and DNA fragmentation (submitted).

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